Combination of a 5-ht4 agonist with a cholinesterase inhibitor

Details Combination of a 5-ht4 agonist with a cholinesterase inhibitor Combination of a 5-ht4 agonist with a cholinesterase inhibitor

A - Human Necessities

61

K

A61K 31/4045 (2006.01) A61K 31/27 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2633470

The present invention relates to a combination of a 5-HT4 receptor agonist and a cholinesterase inhibitor and pharmaceutical compositions and formulations containing the combination. The pharmaceutical combination may be employed for the treatment of alter gastrointestinal motility, sensitivity, secretion or abdominal disorders. The dosage is preferably oral. The preferred 5-HT4 receptor agonist is tegaserod.

La présente invention concerne une combinaison d'un agoniste de récepteur de 5-HT4 et d'un inhibiteur de cholinestérase et des compositions et formulations pharmaceutiques contenant la combinaison. La combinaison pharmaceutique peut être utilisée pour le traitement de motilité, sensibilité et sécrétion gastro-intestinales altérées ou de troubles abdominaux. La forme pharmaceutique est de préférence orale. L'agoniste de récepteur de 5-HT<SUB>4</SUB> préféré est le tégasérod.

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