A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/401 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2552937
The invention relates to a pharmaceutical combination which comprises (a) a DNA topoisomerase inhibitor compound and (b) a compound that inhibits the caspase-9 inhibiting properties of an inhibitor of apoptosis protein (IAP) for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.
L'invention concerne une composition pharmaceutique contenant (a) un composé inhibiteur d'ADN topoisomérase et (b) un composé inhibant les propriétés inhibitrices de caspase-9 d'un inhibiteur de protéines d'apoptose (IAP) pour traiter une maladie proliférative, en particulier, une tumeur solide. Elle concerne également une composition pharmaceutique contenant cette combinaison, l'utilisation de cette combinaison afin de préparer un médicament pour le traitement d'une maladie proliférative, un emballage commercial ou un produit comprenant cette combinaison sous forme de préparation combinée à usage simultané, séparé ou consécutif, ainsi qu'une méthode de traitement d'un animal à sang chaud, particulièrement, un humain.
Fetherstonhaugh & Co.
Novartis Ag
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