Combination of a cannabinoid-1- receptor-antagonist and a...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61K 31/404 (2006.01) A61K 31/437 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2609783

Combination therapies for treating obesity or related eating disorders and/or reducing food consumption are described herein which comprises administering a therapeutically effective amount of a cannabinoid-1 (CB-1) receptor antagonist and an intestinal-acting microsomal triglyceride transfer protein inhibitor (MTPi) to an animal in need of such treatment. The CB-1 receptor antagonist and intestinal-acting MTPi may be administered separately or together.

L'invention concerne des polythérapies destinées à traiter l'obésité ou des troubles de l'alimentation associés et/ou à réduire la consommation alimentaire, et consistant à administrer une dose thérapeutiquement efficace d'un antagoniste du récepteur cannabinoïde 1 (CB-1) et d'un inhibiteur de la protéine microsomale de transfert des triglycérides (MTPi) à action intestinale à un animal nécessitant un tel traitement. L'antagoniste du récepteur CB-1 et le MTPi à action intestinale peuvent être administrés séparément ou ensemble.

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