Combination of a histone deacetylase inhibitor with a death...

Details Combination of a histone deacetylase inhibitor with a death... Combination of a histone deacetylase inhibitor with a death...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2539000

The invention relates to a method of preventing or treating proliferative diseases such as cancer in a mammal, particularly a human, with a combination of pharmaceutical agents which comprises: (a) an HDAI; and (b) a death receptor ligand. The invention further relates to pharmaceutical compositions comprising: (a) an HDAI; (b) death receptor ligand; and (c) a pharmaceutically acceptable carrier. The present invention further relates to a commercial package or product comprising: (a) a pharmaceutical formulation of an HDAI; and (b) a pharmaceutical formulation of death receptor ligand for simultaneous, concurrent, separate or sequential use.

La présente invention se rapporte à une méthode permettant de prévenir ou de traiter des maladies prolifératives telles que le cancer chez un mammifère, en particulier un être humain, avec une combinaison d'agents pharmaceutiques qui comprend : (a) un HDAI ; et (b) un ligand des récepteurs de mort. L'invention a également trait à des compositions pharmaceutiques contenant : (a) un HDAI ; (b) un ligand des récepteurs de mort ; et (c) un excipient pharmaceutiquement acceptable. La présente invention concerne aussi un conditionnement ou un produit commercial, qui contient : (a) une préparation pharmaceutique formulation d'un HDAI ; et (b) une préparation pharmaceutique d'un ligand des récepteurs de mort, pour une utilisation simultanée, concurrente, séparée ou séquentielle.

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