A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/437 (2006.01) A61K 45/06 (2006.01) A61P 25/20 (2006.01)
Patent
CA 2617975
The invention concerns the combination of a short-acting hypnotic agent and R- (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4- piperidinemethanol (Compound A) or its prodrug of the Formula II wherein R is C1-C20 alkyl or a pharmaceutically acceptable salt thereof. The combination of this invention is useful in treating a variety of sleep disorders.
La présente invention concerne la combinaison d'un agent hypnotique à action brève et de R-(+)-a-(2,3-diméthoxyphényl)-1-[2-(4-fluorophényl)éthyl]-4-pipéridineméthanol (Composé A) ou de son précurseur de médicament représenté par la Formule II dans laquelle R représente alkyle C1-C20 ou un sel pharmaceutiquement acceptable de ce dernier. La combinaison selon l'invention est utile dans le traitement de divers troubles du sommeil.
Emmons Gary T.
Karson Craig N.
Kongsamut Sathapana
Legoff Corinne M.
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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