Combination of a nitrogen mustard analogue and imatinib for...

Details Combination of a nitrogen mustard analogue and imatinib for... Combination of a nitrogen mustard analogue and imatinib for...

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/196 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2504665

The invention relates to a combination which comprises (a) a nitrogen mustard analogue selected from chlorambucil, chlornaphazine, estramustine, mechlorethamine, mechlorethamine oxide hydrochloride, navembichin, phenestrine, prednimustine, trofosfamide or uracil mustard and (b) 4-(4- methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4pyridin-3-yl)pyrimidin-2- ylamino)phenylJ-benzamide of formula (I) or a pharmaceutically acceptable salt thereof, the invention pertains to the use of said combination for the treatment chronic lymphocytic leukemia.

L'invention concerne une combinaison contenant (a) un analogue d'azote de la moutarde sélectionné parmi chlorambucile, chlornaphazine, estramustine, mechloréthamine, chlorhydrate d'oxyde de mechloréthamine, navembichine, phenestrine, prednimustine, trofosfamide ou la moutarde à l'uracile et (b) 4-(4-méthylpiperazin-1-ylméthyl)-N-(4-méthyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phényl]-benzamide de la formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, l'invention concernant également l'utilisation de ladite combinaison pour le traitement de la leucémie lymphoïde chronique.

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