Combination of a nucleic acid and a vasoactive agent for...

Details Combination of a nucleic acid and a vasoactive agent for... Combination of a nucleic acid and a vasoactive agent for...

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2320302

Transgene-inserted vectors are effectively used for in vivo gene therapy for peripheral vascular disease, heart disease and other conditions, by direct injection of the vector into arteries supplying the tissue to be targeted, preferably in combination with a vasoactive agent that is infused into the artery prior to or coincident with delivery of the vector.

Dans la thérapie génique in vivo des troubles vasculaires périphériques, des maladies cardiaques et autres pathologies, on obtient de bons résultats avec des vecteurs dans lesquels sont insérés des transgènes. Pour cela, on injecte directement le vecteur dans les artères qui vascularisent le tissu cible, en l'associant de préférence à un agent vasoactif que l'on perfuse dans l'artère. La perfusion d'agent vasoactif se fait avant ou en même temps que l'apport de vecteur.

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