Combination of a nucleoside polymerase inhibitor with a...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/7068 (2006.01) A61K 31/4035 (2006.01) A61P 1/16 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2751220

Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

Les modes de réalisation divulgués dans la présente demande concernent une composition qui peut contenir un inhibiteur de la polymérase du virus de l'hépatite C ou l'un de ses sels ou précurseurs pharmaceutiquement acceptables, et un inhibiteur de la protéase du virus de l'hépatite C ou l'un de ses sels ou précurseurs pharmaceutiquement acceptables. D'autres modes de réalisation divulgués concernent des méthodes de traitement d'une affection pathologique telle qu'une infection par le virus de l'hépatite C, une fibrose hépatique et/ou une altération de la fonction hépatique avec un inhibiteur de la polymérase du virus de l'hépatite C ou l'un de ses sels ou précurseurs pharmaceutiquement acceptables, et un inhibiteur de la protéase du virus de l'hépatite C ou l'un de ses sels ou précurseurs pharmaceutiquement acceptables.

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