Combination of a parp inhibitor and an akt kinase activating...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01)

Patent

CA 2729854

The primary subject of the invention is the use of a PARP inhibitor and an Akt kinase activating compound in combination in the treatment of pathological conditions related to PARP activation and/or that could benefit from Akt activation. A further subject of the invention is the use of a PARP inhibitor and an Akt kinase activating compound in combination for the preparation of pharmaceutical composition or kit for the treatment of a pathological condition related to PARP activation. The invention also relates to pharmaceutical composition, which contains a PARP-inhibitor and an Akt kinase activating compound together with auxiliaries generally used in pharmacy.

Cette invention concerne principalement l'utilisation d'un composé d'activation d'un inhibiteur PARP et d'une Akt kinase en association pour le traitement d'états pathologiques en rapport avec l'activation de PARP et/ou pouvant bénéficier de cette activation. L'invention concerne également l'utilisation d'un composé d'activation d'un inhibiteur PARP et d'une Akt kinase en association pour la préparation d'une composition pharmaceutique ou d'une trousse pour le traitement d'un état pathologique en rapport avec l'activation de PARP. De plus, l'invention concerne une composition pharmaceutique qui contient un composé d'activation d'un inhibiteur PARP et d'une Akt kinase ainsi que des auxiliaires généralement utilisés en pharmacie.

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