Combination of a phosphatidylinositol-3-kinase (pi3k)...

A - Human Necessities – 61 – K

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A61K 31/5377 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2736361

The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound of formula (I) and (b) a mTOR inhibitor for the treatment of a target of raparnycin (mTOR) kinase dependent disease, especially a cancer disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm- blooded animal, especially a human.

Linvention concerne une combinaison pharmaceutique qui renferme (a) un composé inhibiteur de la phosphatidylinositol-3-kinase de formule (I) et (b) un inhibiteur de mTOR, pour le traitement dune cible de maladie dépendante de la rapamycine (mTOR) kinase, spécialement une maladie cancéreuse ; une composition pharmaceutique renfermant une telle combinaison ; lutilisation dune telle combinaison pour la préparation dun médicament destiné au traitement dune maladie proliférative ; un conditionnement commercial ou un produit renfermant une telle combinaison sous la forme dune préparation combinée en vue dune utilisation simultanée, séparée ou séquentielle ; et une méthode de traitement dun animal à sang chaud, spécialement un être humain.

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