Combination of ad-p53 and chemotherapy for the treatment of...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2557326

The present invention relates to the use of p53 gene therapy to treat recurrent cancers in combination with a radio- or chemotherapy. Patients with recurring cancers are treated with a p53 expression construct followed by subsequent radio- or chemotherapy treatment.. Viral and non-viral delivery systems, as well as various radio- and chemotherapy regimens are disclosed.

L'invention se rapporte à l'utilisation de la thérapie génique p53 afin de traiter des réapparitions de cancers en combinaison avec une radiothérapie ou chimiothérapie. Les patients atteints par une réapparition du cancer sont traités au moyen d'une construction d'expression p53 suivie d'un traitement ultérieur par radiothérapie ou chimiothérapie. Elle concerne aussi des systèmes de d'administration viraux et non-viraux, ainsi que différents régimes de radiothérapie et chimiothérapie.

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