A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7072 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2651232
Co-administration of alovudine and zidovudine at ratios considerably in excess of the prior art completely or substantially abolishes the mitochondrial toxicity of alovudine in mitochondrial DNA depletion experiments. The invention thus provides pharmaceutical compositions comprising alovudine and zidovudine in a molar ratio in the range 1 :100 to 1 :350 and methods for the treatment or prophylaxis of multiply resistant HIV comprising the simultaneous or consequential administration of alovudine and zidovudine in the characteristic molar ratio.
L'invention concerne la co-administration d'alovudine et de zidovudine en proportions considérablement en excès par rapport à l'art antérieur pour abolir complètement ou sensiblement la toxicité mitochondriale de l'alovudine dans des expériences d'épuisement d'ADN mitochondrial. L'invention permet donc d'obtenir des compositions pharmaceutiques qui comprennent de l'alovudine et de la zidovudine en proportion molaire dans la plage de 1:100 à 1:350 et des méthodes de traitement ou de prophylaxie de multiplication du VIH résistant qui consistent à administrer simultanément ou conséquemment de l'alovudine et de la zidovudine en proportion molaire caractéristique.
Oberg Bo
Zhang Hong
Gowling Lafleur Henderson Llp
Medivir Ab
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