A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/365 (2006.01) A61K 31/47 (2006.01) A61K 31/7028 (2006.01) A61K 31/706 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2482593
The present invention relates to the use of a first agent that attenuates Topoisomerase I (Topo I) activity and a second agent that inhibits Heat Shock Protein 90 (HSP90) for use in chemotherapy. The agents are particularly useful in the treatment of cancer and destruction of micro-organisms. The invention also relates to screening methods, diagnostic methods and methods for evaluating or monitoring chemotherapy regimens.
L'invention concerne l'utilisation d'un premier agent qui atténue l'activité de la topoisomérase I (Topo I) et d'un second agent qui inhibe la protéine du choc thermique 90 (HSP90), à utiliser en chimiothérapie. Ces agents sont particulièrement utiles dans le traitement du cancer et dans la destruction de micro-organismes. L'invention concerne également des méthodes de criblage, des méthodes diagnostiques ainsi que des méthodes d'évaluation ou de contrôle de régimes de chimiothérapie.
Marks & Clerk
University Of Liverpool
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