Combination of an allosteric inhibitor of matrix...

A - Human Necessities – 61 – K

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Details

A61K 31/5377 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2572324

This invention relates to a combination of an allosteric inhibitor of matrix metalloproteinase-13, or a pharmaceutically acceptable salt thereof, and a ligand to an alpha-2-delta receptor, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the combination, and a method of using the combination to treat a disease or disorder in a mammal suffering therefrom, wherein the disease or disorder is responsive to treatment in one aspect by an allosteric inhibitor of MMP-13 and in the same or a different aspect by a ligand to an alpha-2-delta receptor.

L'invention concerne une combinaison d'un inhibiteur allostérique d'une métalloprotéinase-13 matricielle ou un de ses sels pharmaceutiquement acceptables et d'un ligand à un récepteur alpha-2-delta ou un de ses sels pharmaceutiquement acceptables, une composition pharmaceutique qui contient cette combinaison, et un procédé d'utilisation de la combinaison pour traiter une maladie ou un trouble chez un mammifère souffrant de cette maladie ou de ce trouble, un aspect de la maladie ou du trouble répondant au traitement par un inhibiteur allostérique de la MMP-13 et le même ou un autre aspect de la maladie ou du trouble répondant au traitement par un ligand à un récepteur alpha-2-delta.

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