Combination of an angiotensin ii receptor blocker, a calcium...

A - Human Necessities – 61 – K

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Details

A61K 45/06 (2006.01) A61K 31/41 (2006.01) A61K 31/4422 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2626682

The present invention relates to a combination comprising: (a) an angiotensin II receptor blocker (ARB), or a pharmaceutically acceptable salt thereof; (b) a calcium channel blocker (CCB), or a pharmaceutically acceptable salt thereof; and (c) one of the two active agents selected from (i) a renin inhibitor, or a pharmaceutically acceptable salt thereof; and (ii) a neutral endopeptidase (NEP) inhibitor, or a pharmaceutically acceptable salt thereof; for the prevention of, delay the onset of and/or treatment of cardiovascular disorders, which method comprises administering to a warm-blooded animal, in need thereof, a therapeutically effective amount of a combination of the present invention.

La présente invention concerne une combinaison comprenant : (a) un bloqueur du récepteur de l'angiotensine II (ARB), ou l'un de ses sels pharmaceutiquement acceptables; (b) un bloqueur de canal sodique (CCB), ou l'un de ses sels pharmaceutiquement acceptables; et (c) un agent actif choisi parmi les deux suivants : (i) un inhibiteur de rénine, ou l'un de ses sels pharmaceutiquement acceptables; et (ii) un inhibiteur de l'endopeptidase neutre (NEP), ou l'un de ses sels pharmaceutiquement acceptables. Pour éviter, retarder l'apparition ou traiter des troubles cardiovasculaires chez un animal à sang chaud, un procédé implique d'administrer à cet animal une quantité efficace sur le plan thérapeutique d'une combinaison de la présente invention.

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