A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61K 51/10 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2650953
The invention relates to a combination (i) of a fusion protein, comprising an .epsilon.s2-CH4 domain part and an antibody part, specifically recognising the extra domain B of fibronectin (ED-B - fibronectin), and (ii) and an anti-EGFR-antibody and its use for treatment of cancer, in particular head and neck cancer, non-small cell lung cancer, prostate cancer, colorectal cancer, ovarian cancer, pancreatic cancer, gastric cancer, and / or breast cancer.
L'invention porte sur une combinaison (i) d'une protéine de fusion comprenant une partie de domaine .epsilon.s2-CH4 et une partie d'un anticorps reconnaissant spécifiquement l'extradomaine B de la fibronectine (ED-B - fibronectine), et (ii) un anticorps anti-EGFR, et sur ses utilisations pour le traitement de cancers, en particulier de la tête et du cou, du poumon hors petites cellules, de la prostate, de l'estomac et/ou du sein.
Berndorff Dietmar
Dinkelborg Ludger
Sieger Stephanie
Tijink Bernhard Marcel
Van Dongen Augustinus Antonius Maria Silvester
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
Vereniging Vu-Windesheim
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