Combination of an aromatase inhibitor with a bisphosphonate

Details Combination of an aromatase inhibitor with a bisphosphonate Combination of an aromatase inhibitor with a bisphosphonate

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61K 31/35 (2006.01) A61K 31/4196 (2006.01) A61K 45/06 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2494345

The present invention provides a combination for the treatment of a disease or condition which responds to aromatase inhibition, in particular a proliferative disease, especially a malignant disease such as breast cancer or similar soft tissue endocrine-sensitive cancer, most preferably breast cancer, comprising an aromatase inhibitor and a bisphosphonate for simultaneous, concurrent, separate or sequential use in the prevention of bone loss which is caused by the treatment with an aromatase inhibitor. Also provided is a method of treating a patient suffering from a disease or condition which responds to aromatase inhibition comprising administering to the patient an effective amount of a bisphosphonate and an effective amount of an aromatase inhibitor.

La présente invention concerne une combinaison destinée au traitement d'une maladie ou d'un état qui réagit à l'inhibition de l'aromatase, en particulier d'une maladie proliférative, singulièrement d'une maladie maligne telle qu'un cancer du sein ou un cancer analogue des tissus mous sensible aux sécrétions endocrines, mais de préférence un cancer du sein. Cette combinaison comprend un inhibiteur de l'aromatase et un biphosphonate pour utilisation simultanée, concurrente, séparée ou séquentielle en vue de la prévention d'une perte de masse osseuse provoquée chez un patient par le traitement au moyen d'un inhibiteur de l'aromatase. L'invention concerne également une méthode de traitement d'un patient souffrant d'une maladie ou d'un état réagissant à une inhibition de l'aromatase, qui consiste à lui administrer une dose efficace de bisphosphonate et une dose efficace d'un inhibiteur de l'aromatase.

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