Combination of an nmda receptor antagonist and a selective...

A - Human Necessities – 61 – K

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A61K 31/13 (2006.01) A61K 31/16 (2006.01)

Patent

CA 2528622

The present invention provides a method for the treatment of depression, including treatment-resistant depression, and other mood disorders using a combination of an NMDA receptor antagonist and a SSRI that is citalopram or escitalopram. It has unexpectedly been shown that the combination has a synergistic and potentiated effect of either compound as monotherapy, resulting in an enhanced therapeutic effect at lower doses.

L'invention se rapporte à un procédé de traitement de la dépression, y compris la dépression résistant aux traitements, et d'autres troubles de l'humeur au moyen d'une combinaison d'un antagoniste du récepteur NMDA et d'un SSRI qui consiste en citaloprame ou escitaloprame. Il a été prouvé de manière inattendue que cette combinaison possède un effet synergistique et potentialisé de n'importe quel composé en tant que monothérapie, ce qui permet d'obtenir un meilleur effet thérapeutique à des doses inférieures.

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