Combination of angiopoietin-2 antagonist and of vegf-a, kdr...

Details Combination of angiopoietin-2 antagonist and of vegf-a, kdr... Combination of angiopoietin-2 antagonist and of vegf-a, kdr...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2633211

The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.

L'invention porte sur des agents à activité antiangiogène et donc utiles dans des méthodes de traitement d'états morbides associés à l'angiogenèse, chez l'animal ou l'homme. L'invention porte sur plus spécifiquement, sur la combinaison d'un antagoniste de l'activité biologique de l'angiopoïétine 2 et d'un antagoniste de l'activité biologique du VEGF-A et/ou du KDR et/ou du Fltl, et sur les utilisations de tels antagonistes.

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