Combination of angiotensin converting enzyme inhibitor and...

Details Combination of angiotensin converting enzyme inhibitor and... Combination of angiotensin converting enzyme inhibitor and...

A - Human Necessities

61

K

A61K 38/05 (2006.01) A61K 31/585 (2006.01) A61K 38/08 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2212713

Combinations of an ACE inhibitor and an aldosterone receptor antagonist are described for use in treatment of circulatory disorders. Of particular interest are therapies using captopril or enalapril co-administered with a low- dose of spironolactone. This co-therapy would be particularly useful to treat or prevent the progression of congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.

L'invention concerne des combinaisons d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un antagoniste du récepteur de l'aldostérone destinées à être utilisées dans le traitement de troubles circulatoires. Elle concerne surtout des thérapies dans lesquelles du captopril ou de l'énalapril sont co-administrés avec une faible dose de spironolactone. Cette thérapie combinée est particulièrement utile pour traiter ou prévenir la progression de l'insuffisance cardiaque congestive et supprimer ou réduire les effets secondaires induits par l'antagoniste de l'aldostérone, tels que l'hyperkaliémie.

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