Combination of anti-angiogenic substance and anti-tumor...

A - Human Necessities – 61 – K

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A61K 31/47 (2006.01) A61K 31/194 (2006.01) A61K 31/282 (2006.01) A61K 33/24 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2704000

The problems of the present invention are to find a pharmaceutical composition and a method for treating cancer that exhibit excellent anti-tumor effect. Excellent antitumor effect is achieved when 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6- quinolinecarboxamide or an analogous compound thereof, a pharmacologically acceptable salt thereof or a solvate thereof is used in combination with an anti-tumor platinum complex.

La présente invention a pour objet de découvrir une composition pharmaceutique possédant un excellent effet antitumoral et un procédé thérapeutique pour le cancer. Le 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophénoxy)-7-méthoxy-6-quinoléine-carboxamide, un composé analogue ou l'un de ses sels acceptables sur le plan pharmacologique, ou un solvate du composé, le composé analogue ou le sel acceptable sur le plan pharmacologique pouvant présenter un excellent effet antitumoral lorsqu'ils sont utilisés en combinaison avec un complexe de platine antitumoral.

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