A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/43 (2006.01) A61K 31/00 (2006.01) A61K 31/275 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/473 (2006.01) A61K 31/545 (2006.01) A61K 45/06 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01)
Patent
CA 2367149
The present invention is drawn to methods of killing bacteria, including antibiotic resistant bacteria, by contacting said bacteria with a membrane permeabilizing compound or combination of compounds and a membrane impermeant toxic agent or combination of agents, resulting in the death of the bacteria without substantial injury to the infected host or patient. The present invention is further drawn to compositions and kits for effecting the method of the present invention. The present invention is further drawn to methods of rendering toxic agents such as toxic organic molecules, membrane impermeant for use in the methods and compositions of the present invention.
La présente invention concerne des procédés de suppression de bactéries, y compris des bactéries résistantes aux antibiotiques, consistant à mettre en contact ces bactéries avec un composé, ou une combinaison de composés, de perméabilisation de membranes, et un agent toxique, ou une combinaison d'agents, ne pénétrant pas les membranes, ce qui provoque la mort des bactéries sans pratiquement d'effet secondaire pour le patient ou l'hôte infecté. L'invention concerne aussi des compositions et des nécessaires destinés à mettre en oeuvre le procédé de l'invention. Elle concerne encore des procédés permettant de rendre non pénétrants des agents toxiques, tels que des molécules organiques toxiques, de manière à les utiliser dans les procédés et les compositions de l'invention.
Borden Ladner Gervais Llp
P.c. Howard M. Shapiro M.d.
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