Combination of antineoplastic agent and antisense...

Details Combination of antineoplastic agent and antisense... Combination of antineoplastic agent and antisense...

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 31/70 (2006.01) A61K 35/28 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2147663

Therapeutic combinations of an antisense oligonucleotide and another, non-oligonucleotide chemotherapeutic agent are provided which allows for a reduced dosage of the non-oligonucleotide agent, and hence, reduced toxicity to the host. The anti- sense oligonucleotide component has a nucleotide sequence complementary to at least a portion of the mRNA transcript of a tar- get oncogene or proto-oncongene, the amplification or expression of which is associated with the particular neoplastic disease un- der treatment. The combination is particularly useful in treating leukemias, more particularly as a bone marrow purging agent

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