Combination of azd2171 and pemetrexed

A - Human Necessities – 61 – K

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Details

A61K 31/519 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2631676

The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation, particularly a method for the treatment of a cancer, particularly a cancer involving a solid tumour, which comprises the administration of AZD2171 in combination with pemetrexed; to a pharmaceutical composition comprising AZD2171 and pemetrexed; to a combination product comprising AZD2171 and pemetrexed for use in a method of treatment of a human or animal body by therapy; to a kit comprising AZD2171 and pemetrexed; to the use of AZD2171 and pemetrexed in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation.

La présente invention concerne une méthode visant à produire un effet antiangiogénique et/ou de réduction de la perméabilité vasculaire chez un animal à sang chaud, tel qu'un être humain, qui est éventuellement traité par rayonnement ionisant. L'invention concerne notamment une méthode de traitement d'un cancer, en particulier un cancer comportant une tumeur solide. Cette méthode consiste à administrer AZD2171 en combinaison avec le pemetrexed. L'invention concerne également une composition pharmaceutique comprenant AZD2171 et le pemetrexed; un produit de combinaison comprenant AZD2171 et le pemetrexed et destiné à être utilisé dans une méthode de traitement destinée à un être humain ou à un animal; un kit comprenant AZD2171 et le pemetrexed; l'utilisation d'AZD2171 et du pemetrexed dans la fabrication d'un médicament destiné à être utilisé dans la production d'un effet antiangiogénique et/ou de réduction de la perméabilité vasculaire chez un animal à sang chaud, tel qu'un être humain, éventuellement traité par rayonnement ionisant.

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