Combination of .beta.-adrenoceptor antagonists and...

A - Human Necessities – 61 – K

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A61K 31/165 (2006.01) A61K 31/04 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1200206

-12- ABSTRACT OF THE DISCLOSURE A .beta.-adrenoceptor antagonist, which does not penetrate or penetrates poorly the brain, is combined with subthernpeutic doses of an anxiolytic agent, such as diazepam, to give a method, and pharmaceutical or veterinary com- position, for treating anxiety, stress or aggressivity without deleterious side effects associated with the central nervous system.

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