Combination of bisphosphonate and tetracycline

A - Human Necessities – 01 – N

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A01N 37/18 (2006.01) A01N 57/00 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2343098

Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts. The effectiveness of such compositions can be demonstrated in standard tests, for example by measuring tooth mobility.

L'invention concerne le traitement ou la prévention de la destruction de tissus due à une activité excessive de protéinase dans un système biologique par l'administration au système d'une composition qui combine une tétracycline et une bisphosphonate, en quantités synergétiques inhibitrices de protéinase. L'efficacité de ces compositions peut être démontrée par des essais types, par exemple par la mesure de la mobilité dentaire.

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