Combination of cytochome p450 dependent protease inhibitors

Details Combination of cytochome p450 dependent protease inhibitors Combination of cytochome p450 dependent protease inhibitors

A - Human Necessities

61

K

A61K 31/427 (2006.01) A61K 31/34 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2469343

The present invention relates to a method for improving the pharmacokinetics of HIV protease inhibitors containing hexahydrofuro[2,3-b]furanyl, of Formula 4: (see formula I) comprising administering to a human in need thereof a combination of a therapeutically effective amount of a hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitor, and a therapeutically effective amount of a cytochrom P450 inhibitor.

L'invention concerne un procédé permettant d'améliorer la pharmacocinétique d'inhibiteurs de protéase du VIH contenant de l'hexahydrofuro[2,3-b]furanyle, qui consiste à administrer à un patient une combinaison de quantité thérapeutiquement efficace d'inhibiteur de protéase du VIH contenant de l'hexahydrofuro[2,3-b]furanyle, et de quantité thérapeutiquement efficace d'inhibiteur de cytochrome P450.

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