Combination of cytokine and cytokine receptor for altering...

Details Combination of cytokine and cytokine receptor for altering... Combination of cytokine and cytokine receptor for altering...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/19 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2646931

The invention provides a pharmaceutical composition including a cytokine and a peptide comprising at least a portion of a chemokine receptor or a c_protein coupled receptor. The pharmaceutical composition of the invention may be used for altering immune system functioning, for example, to treat an immune system disorder, such as an autoimmune disease, multiple sclerosis, transplant rejection, psoriasis and asthma. The invention also provides peptides that may be used in the pharmaceutical composition and a method for preparing the pharmaceutical composition of the invention. The invention further provides a method for to treating an immune system disorder, such as an autoimmune disease, multiple sclerosis, transplant rejection, and psoriasis asthma.

L'invention concerne une composition pharmaceutique renfermant une cytokine et un peptide comprenant au moins une partie d'un récepteur de chimiokine ou d'un récepteur couplé à une protéine C. La composition pharmaceutique selon l'invention peut être utilisée pour modifier le fonctionnement du système immunitaire, notamment pour traiter un trouble du système immunitaire, tel qu'une maladie autoimmune, la sclérose en plaques, le rejet après transplantation, le psoriasis et l'asthme. L'invention concerne également des peptides qui peuvent être utilisés dans la composition pharmaceutique ainsi qu'un procédé de préparation de ladite composition pharmaceutique. L'invention concerne encore un procédé de traitement d'un trouble du système immunitaire, tel qu'une maladie autoimmune, la sclérose en plaques, le rejet après transplantation, le psoriasis et l'asthme.

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