Combination of hcv ns3 protease inhibitor with interferon...

Details Combination of hcv ns3 protease inhibitor with interferon... Combination of hcv ns3 protease inhibitor with interferon...

A - Human Necessities

61

K

A61K 45/06 (2006.01)

Patent

CA 2737376

The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin. Compound (1) is a selective and potent inhibitor of the HCV NS3 serine protease. The present invention also relates to methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in a patient.

Cette invention concerne des combinaisons thérapeutiques comprenant (a) le composé (1), ou un sel pharmaceutiquement acceptable de celui-ci, tel que ci-décrit, (b) un interféron alpha et (c) de la ribavirine. Le composé (1) est un inhibiteur sélectif et puissant de la sérine protéase NS3 du VHC. La présente invention concerne également des procédés d'utilisation desdites combinaisons thérapeutiques pour traiter une infection par le VHC ou soulager un ou plusieurs de ses symptômes chez un patient.

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