Combination of histone deacetylase inhibitors with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/16 (2006.01) A61K 31/4045 (2006.01) A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 31/704 (2006.01) A61K 31/7068 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2526908

The invention relates to a combination which comprises (a) one or more chemotherapeutic agents and (b) a histone deacetylase inhibitor ("HDAI") for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases including pre-malignant lesions (e.g. colon polyps) and malignancies, both solid and undifferentiated or other proliferative diseases in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of preventing or treating proliferative diseases including pre- malignant lesions (e.g. colon polyps) and malignancies, both solid and undifferentiated or other proliferative diseases, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.

L'invention concerne une combinaison comprenant (a) un ou plusieurs agents chimiothérapeutiques, et (b) un inhibiteur d'histone déacétylase (<= HDAI >=) pour l'utilisation simultanée, concurrente,séparée ou séquentielle, notamment pour l'utilisation dans le traitement de maladies proliférantes, y compris des lésions précancéreuses (par exemple, polype du colon) et des tumeurs malignes, tumeurs solides et maladies indifférenciées ou autres maladies proliférantes chez un mammifère, en particulier, un être humain. L'invention concerne également des compositions pharmaceutiques comprenant une telle combinaison, et un procédé de prévention ou de traitement de maladies proliférantes, y compris des lésions précancéreuses (par exemple, polype du colon) et des tumeurs malignes, tumeurs solides et maladies indifférenciées ou autres maladies proliférantes chez un mammifère, en particulier, un être humain, au moyen d'une telle combinaison. L'invention concerne enfin un emballage commercial ou un produit comprenant une telle combinaison.

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