Combination of igf-1 and igfbp for anabolism

Details Combination of igf-1 and igfbp for anabolism Combination of igf-1 and igfbp for anabolism

A - Human Necessities

61

K

A61K 38/30 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2101340

A method is disclosed for producing an anabolic state in a mammal by co-admin- istration by subcutaneous injection of a combination of effective amounts of IGF-I and an IGF binding protein in a defined molar ratio in the absence of growth hor- mone so as to produce a greater anabolic re- sponse in the mammal than that achieved using IGF-I alone in an amount equal to that used for IGF-I in the combination. Preferably, the IGF-I is native-sequence, mature human IGF-I, the binding protein is IGFBP-3, and the mammal is human or a non-human animal of economic importance such as a cow or pig.

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