Combination of organic compounds

Details Combination of organic compounds Combination of organic compounds

A - Human Necessities

61

K

A61K 31/549 (2006.01) A61K 31/216 (2006.01) A61K 31/41 (2006.01) A61K 31/445 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2596485

Abstract of the Disclosure The present invention relates to a combination comprising: (i) a renin inhibitor, or a pharmaceutically acceptable salt thereof; (ii) a neutral endopeptidase (NEP) inhibitor, or a pharmaceutically acceptable salt thereof; and optionally at least one therapeutic agent selected from the group consisting of (a) a diuretic, or a pharmaceutically acceptable salt thereof; and (b) an angiotensin II receptor blocker (ARB), or a pharmaceutically acceptable salt thereof; for the prevention of, delay the onset of and/or treatment of a disease or a condition mediated by angiotensin II and/or NEP activity, which method comprises administering to a warm-blooded animal, in need thereof, a therapeutically effective amount of a combination of the present invention.

La présente invention concerne une combinaison renfermant: (i) un inhibiteur de rénine, ou son sel pharmaceutiquement acceptable; (ii) un inhibiteur d'endopeptidase neutre (NEP) ou bien son sel pharmaceutiquement acceptable et facultativement au moins un agent thérapeutique choisi dans le groupe contenant: (a) un diurétique ou son sel pharmaceutiquement acceptable et (b) un bloqueur du récepteur d'angiotensine II (ARB) ou son sel pharmaceutiquement acceptable, pour la prévention, le retard de l'apparition ou le traitement d'une maladie ou d'un état médié par l'activité de l'angiotensine II et/ou d'EPN, ce procédé consistant à administrer à un animal à sang chaud, en situation de nécessité, une dose thérapeutique efficace d'une combinaison de la présente invention.

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