Combination of polychitosamine and hmg-coa reductase...

A - Human Necessities – 61 – K

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A61K 31/722 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2580460

Combinations of therapeutic compounds for prophylaxis or treatment of hyperlipidemia and hyperlipidemia related disorders, such as hypercholesterolemia and the resultant atherosclerosis in a mammal. The combinations are useful for reducing serum cholesterol, and/or cholesteryl ester, triglycerides, phospholipids and fatty acids in a mammal. The methods of the preferred embodiments comprise administering to a mammal a first amount of polychitosamine and a second amount of an HMG-CoA reductase inhibitor (statin).

L'invention concerne des combinaisons de composés thérapeutiques destinés à la prévention ou au traitement de l'hyperlipidémie et des troubles apparentés à l'hyperlipidémie, tels que l'hypercholestérolémie et l'athérosclérose résultante chez le mammifère. Ces combinaisons sont indiquées pour réduire le cholestérol sérique, et/ou les esters de cholestéryle, les triglycérides, les phospholipides et les acides gras chez le mammifère. Dans les modes de mise en oeuvre préférés, les méthodes décrites consistent à administrer à un mammifère une première dose de polychitosamine, et une seconde dose d'un inhibiteur de l'HMG-CoA réductase (statine).

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