A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61K 31/135 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/575 (2006.01)
Patent
CA 2174327
This invention describes the use of at least one compound having a progesterone-antagonistic (PA) action and at least one compound having an antiestrogenic (A?) action with a simultaneous partial agonistic action for the production of pharmaceutical agents for hormone substitution therapy (HRT) for perimenopausal and postmenopausal women. In the case of combined use of progesterone antagonist and antiestrogen, the stimulation of the endometrium by the progesterone antagonist that is caused by its partial agonistic action when an antiestrogen is used by itself is inhibited. For example, a pharmaceutical agent according to the invention contains onapristone (progesterone antagonist) and tamoxifen (antiestrogen).
La présente invention décrit l'utilisation d'au moins un composé à action antagoniste de la progestérone (PA) et d'au moins un composé à action anti-oestrogène (AÖ) et à action partiellement agoniste simultanée pour la préparation de médicaments destinés à l'hormonothérapie substitutive des femmes péri ou postménopausées. L'utilisation combinée de PA et AÖ a pour effet d'inhiber par le PA la stimulation de l'endomètre provoquée par la seule utilisation d'un AÖ du fait de l'action partiellement agoniste de celui-ci. Un médicament objet de l'invention contient par exemple de l'onapriston (PA) et du tamoxifène (AÖ)
Chwalisz Kristof
Stockemann Klaus
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Schering Aktiengesellschaft
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