Combination of progesterone-receptor antagonist together...

Details Combination of progesterone-receptor antagonist together... Combination of progesterone-receptor antagonist together...

A - Human Necessities

61

K

A61K 45/06 (2006.01)

Patent

CA 2684806

The present invention relates to the combination of the progesterone-receptor antagonist 11 .beta.-(4-acetylphenyl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2, 2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one aromatase inhibitor and to the use of said combination for the prophylaxis and treatment of BRCA1- or BRCA2-mediated diseases. Aromatase inhibitors which can be combined together with the compound 11 .beta.-(4-acetylphenyl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2,2 pentafluoroethyl)- estra-4,9-dien-3-one are for example aminoglutethimide, fadrozole, anastrozole, letrozole, vorozole, formestane, exemestane and atamestane.

La présente invention concerne la combinaison de l'antagoniste du récepteur de la progestérone 11.beta.-(4-acétylphényl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2, 2-pentafluoroéthyl)-estra-4,9-dién-3-one, ou d'un dérivé ou d'un analogue pharmaceutiquement acceptable de celui-ci, avec au moins un inhibiteur de l'aromatase, ainsi que l'utilisation de cette combinaison pour la prévention et le traitement de maladies médiées par BRCA1 ou BRCA2. Les inhibiteurs de l'aromatase susceptibles d'être combinés avec le composé 11.beta.-(4-acétylphényl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2, 2-pentafluoroéthyl)-estra-4,9-dién-3-one sont, par exemple, l'aminoglutéthimide, le fadrozole, l'anastrozole, le létrozole, le vorozole, le formestane, l'exémestane et l'atamestane.

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