Combination of progesterone-receptor antagonist together...

Details Combination of progesterone-receptor antagonist together... Combination of progesterone-receptor antagonist together...

A - Human Necessities

61

K

A61K 31/57 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2683517

The present invention relates to the combination of the progesterone-receptor antagonist 11 .beta.-(4-acetylphenyl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2,2-pentafluoroethyl)- estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one lutein-hormone-releasing hormone agonist or antagonist and to the use of said combination for the prophylaxis and treatment of BRCA1- or BRCA2-mediated diseases. Lutein-hormone-releasing hormone agonists and antagonists, which can be combined together with the compound 11 .beta.-(4-acetylphenyl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2,2 pentafluoroethyl)- estra-4,9-dien-3-one are for example gonadorelin, goserelin, triptorelin, buserelin, nafarelin, deslorelin, histrelin, antide, ramorelix, cetrorelix, antarelix, ORG30850, abarelix, ganirelix and leuprolin.

La présente invention concerne la combinaison de l'antagoniste du récepteur de la progestérone 11.beta.-(4-acétylphényl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2,2-pentafluoroéthyl)-estra-4,9-dién-3-one, ou d'un dérivé ou d'un analogue pharmaceutiquement acceptable de celui-ci, avec au moins un agoniste ou un antagoniste de la lutéolibérine, ainsi que l'utilisation de cette combinaison pour la prévention et le traitement de maladies médiées par BRCA1 ou BRCA2. Les agonistes et les antagonistes de la lutéolibérine susceptibles d'être combinés avec le composé 11.beta.-(4-acétylphényl)-17.beta.-hydroxy-17.alpha.-(1,1,2,2,2-pentafluoroéthyl)-estra-4,9-dién-3-one sont, par exemple, la gonadoréline, la goséréline, la triptoréline, la buséréline, la nafaréline, la desloréline, l'histréline, l'antide, le ramorélix, le cétrorélix, l'antarélix, ORG30850, l'abarélix, le ganirélix et la leuproline.

Affiliated with

Also associated with

Rating

Combination of progesterone-receptor antagonist together... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combination of progesterone-receptor antagonist together..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combination of progesterone-receptor antagonist together... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2024790