A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/04 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2334527
The present invention relates to the use of selenium and/or a derivative thereof in combination with one or more cytostatics. It is the object of the present invention to provide a possibility of enhancing the effect of antitumor drugs, and to provide said drugs in a suitable form of administration. Said object is achieved by using selenium and/or at least one selenium compound for enhancing the effect of one or more cytostatics. This combination results in a synergistic, i.e. superadditive, enhancement of the effect. Furthermore, the present invention provides a kit containing selenium and/or at least one selenium compound and one or more cytostatics as a combination preparation for cytostatic therapy. The present invention can be used efficiently against various types of tumor cells, but especially against large-cell and small-cell bronchial carcinomas, adenocarcinomas, pancreatic carcinomas, prostatic carcinomas and hypernephromas.
L'invention concerne l'utilisation de sélénium et/ou d'un de ses dérivés, en combinaison avec un ou plusieurs agents cytostatiques. L'invention vise à permettre d'intensifier l'action antitumorale de principes actifs et de mettre lesdits principes actifs à disposition sous une forme galénique appropriée. A cet effet, il est prévu d'utiliser du sélénium et/ou au moins un composé sélénium pour intensifier l'action d'un ou de plusieurs agents cytostatiques. Cette combinaison entraîne une intensification synergique de l'action, c.-à-d. suradditive. L'invention concerne en outre un kit contenant du sélénium et/ou au moins un composé sélénium et un ou plusieurs agents cytostatiques comme préparation combinée pour la thérapie cytostatique. Cette invention s'utilise pour traiter différents types de cellules tumorales, et plus particulièrement le cancer des bronches, l'adénocarcinome, le cancer du pancréas, le cancer de la prostate et l'hypernéphrome.
Rohrer Helmut
Stiefel Thomas
Biosyn Arzneimittel Gmbh
Borden Ladner Gervais Llp
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