Combination of serotonin agonist (5ht2) and antagonist...

Details Combination of serotonin agonist (5ht2) and antagonist... Combination of serotonin agonist (5ht2) and antagonist...

A - Human Necessities

61

K

A61K 31/497 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) A61P 3/04 (2006.01) C07C 311/51 (2006.01)

Patent

CA 2411192

The invention relates to a method of preventing or treating a disease related to the 5-HT2C receptor and the 5-HT6 receptor, comprising administering to a human or animal subject in need thereof a 5-HT2C receptor agonist and a 5-HT6 receptor antagonist in sufficient amounts to provide a therapeutic affect. The invention also relates to a pharmaceutical composition comprising an effective amount of a combination of a 5-HT2C receptor agonist and a 5-HT6 receptor antagonist, and optionally a pharmaceutically acceptable carrier.

L'invention concerne un procédé permettant de prévenir ou de traiter une maladie liée au récepteur 5-HT¿2C? et au récepteur 5-HT¿6?. Ce procédé consiste à administrer à un sujet humain ou animal en ayant besoin un agoniste du récepteur 5-HT¿2C? et un antagoniste du récepteur 5-HT¿6 ? en quantité suffisante pour produire un effet thérapeutique. L'invention concerne également une composition pharmaceutique contenant une association d'un agoniste du récepteur 5-HT¿2C ? et d'un antagoniste du récepteur 5-HT¿6 ? en quantité efficace, et éventuellement un excipient pharmaceutiquement acceptable.

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