Combination of serotonin reuptake inhibitors and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/5375 (2006.01) A61K 31/135 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2542339

This invention is directed in one embodiment to pharmaceutical compositions and methods for treating depression in a mammal. To a mammal in need of such treatment are administered: (i) at least one serotonin reuptake inhibitor or pharmaceutically acceptable salt thereof; and (ii) at least one norepinephrine reuptake inhibitor or pharmaceutically acceptable salt thereof, wherein the norepinephrine reuptake inhibitor is selected from the group consisting of Structure II, Structure III, and Structure IV as defined herein.

Dans un mode de réalisation, l'invention concerne des compositions pharmaceutiques et des méthodes pour traiter la dépression chez un mammifère. Un mammifère nécessitant un tel traitement se voit administrer: (i) au moins un inhibiteur de recaptage de la sérotonine ou bien son sel pharmaceutiquement acceptable; et (ii) au moins un inhibiteur de recaptage de la noradrénaline ou bien son sel pharmaceutiquement acceptable. L'inhibiteur de recaptage de la noradrénaline est choisi dans le groupe comprenant la Structure II, la Structure III, et la Structure IV telles que définies dans le présent fascicule .

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