Combination of squalene synthetase inhibitor and other type...

Details Combination of squalene synthetase inhibitor and other type... Combination of squalene synthetase inhibitor and other type...

A - Human Necessities

61

K

167/179

A61K 31/00 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2007641

HX24 Abstract COMBINATION OF A SQUALENE SYNTHETASE INHIBITOR AND OTHER TYPE OF SERUM CHOLESTEROL REDUCING AGENT AND METHOD FOR LOWERING SERUM CHOLESTEROL USING SUCH COMBINATION A pharmaceutical combination is provided which includes an inhibitor of the enzyme squalene synthetase and a pharmaceutical which reduces serum cholesterol by a mechanism other than inhibiting production of the enzyme HMG CoA reductase or the enzyme squalene synthetase, namely, an antihyperlipoproteinemic agent or antihyperlipemic agent, for example, probucol or gemfibrozil. A method for reducing serum cholesterol or inhibiting formation of or treating atherosclerosis using the above combination is also provided.

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