Combination of tgf-.beta. inhibition and immune stimulation...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 45/06 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2334960

Medicament comprising a combination of - at least one inhibitor of the effect of a substance negatively effecting an immune response, the substance selected from the group consisting of TGF-.beta. and its receptors, VEGF and its receptors, interleukin 10 (IL-10) and its receptors, PGE2 and its receptors, wherein the inhibitor has a molecular weight of less than 100 kDa and - at least one stimulator positively effecting an immune response.

Médicament contenant une combinaison d'au moins un inhibiteur de l'effet d'une substance exerçant un effet négatif sur une réponse immunitaire, cette substance étant sélectionnée dans le groupe constitué par TGF-.beta. et ses récepteurs, VEGF et ses récepteurs, interleukine 10 (IL-10) et ses récepteurs, PGE¿2? et ses récepteurs, cet inhibiteur possédant un poids moléculaire inférieur à 100 kDa, et d'au moins un stimulant exerçant un effet positif sur la réponse immunitaire.

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