Combination of transplantation and oncolytic virus treatment

Details Combination of transplantation and oncolytic virus treatment Combination of transplantation and oncolytic virus treatment

A - Human Necessities

61

K

A61K 35/12 (2006.01) A01N 1/02 (2006.01) A61K 35/14 (2006.01) A61K 35/76 (2006.01) A61K 39/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2460861

Oncolytic viruses can be used to purge cellular compositions to remove undesired neoplastic cells before the cellular compositions are used for transplantation. The present invention relates o the use of a virus to pre-treat a subject prior to delivery into the subject a transplant that has been purged with the same virus. This pre-treatment serves to elicit an immune response in the subject against the virus, thereby protecting the subject from infections by the virus after receiving the transplant, which likely contains infectious viruses.

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