Combination of two or more active ingredients using...

A - Human Necessities – 01 – N

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A01N 43/80 (2006.01) A01N 25/28 (2006.01)

Patent

CA 2339475

Provided is a method of encapsulating clomazone and a second biological agent comprising: (a) mixing (i) an aqueous phase, (ii) an emulsifier and (iii) a water-immiscible phase containing clomazone, the second biological agent, and at least one first polyfunctional compound; (b) forming a dispersion of water- immiscible droplets throughout the aqueous phase; and (c) adding at least one second polyfunctional compound into the dispersion and reacting the second polyfunctional compound(s) with the first polyfunctional compound(s) to form a polymer shell around the water-immiscible droplets. Further provided is a method of preparing an agricultural composition comprising encapsulated clomazone and a second biological agent, the method comprising: (a) providing a suspension of clomazone capsules comprising solutes, diluents or carriers; (b) providing a composition of suspended particles of the second biological agent; (c) adjusting solutes, diluents or carriers in the particle suspension so that the osmolarity of the particle suspension is sufficiently like that of the capsule suspension so that the capsules are not disrupted when the suspensions of steps (a) and (b) are mixed; and (d) mixing the suspensions of steps (a) and (b).

L'invention concerne un procédé d'encapsulation de clomazone et d'un second agent biologique, comprenant les étapes consistant: (a) à mélanger (i) une phase aqueuse, (ii) un émulsifiant et (iii) une phase non miscible dans l'eau et contenant du clomazone, le second agent biologique ainsi qu'au moins un premier composé polyfonctionnel; (b) à former une dispersion de gouttelettes non miscibles dans l'eau dans toute la phase aqueuse, et (c) à ajouter au moins un second composé polyfonctionnel dans la dispersion et à faire réagir ce (ces) second(s) composé(s) polyfonctionnel(s) avec le(s) premier(s) composé(s) polyfonctionnel(s), afin de former une enveloppe polymère autour des gouttelettes non miscibles dans l'eau. En outre, l'invention concerne un procédé de préparation d'une composition agricole contenant du clomazone encapsulé et un second agent biologique, ce procédé comprenant les étapes consistant: (a) à préparer une suspension de capsules de clomazone comprenant des solutés, diluants ou excipients; (b) à préparer une composition de particules suspendues du second agent biologique; (c) à régler les taux des solutés, diluants ou excipients dans la suspension de particules, de manière que l'osmolalité de celle-ci soit suffisamment proche de celle de la suspension de capsules, afin que les capsules ne se rompent pas lors du mélange des suspensions des étapes (a) et (b), et (d) à mélanger les suspensions des étapes (a) et (b).

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