Combination preparation of estrogen and anti-estrogen

Details Combination preparation of estrogen and anti-estrogen Combination preparation of estrogen and anti-estrogen

A - Human Necessities

61

K

A61K 31/565 (2006.01) A61K 31/10 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01)

Patent

CA 2321427

The invention relates to a combination preparation containing an estrogen and an anti-estrogen, characterized in that the estrogen is chosen from the group consisting of 17-.beta.-estradiol, 17-.alpha.-ethinyl estradiol, estriol, estrone, estrone sulfate, estrogen sulfamate, 17-.alpha.-estradiol, mestranol, stilbestrol and natural conjugated estrogens, and in that the anti-estrogen is a substituted 7.alpha.-(-aminoalkyl)-estratriene of the general formula (I). The combination preparation provided for in the invention can be used for hormone replacement therapy.

L'invention concerne une préparation combinée d'un oestrogène et d'un anti-oestrogène, caractérisée en ce que l'oestrogène est choisi dans le groupe constitué de 17-.beta.-oestradiol, 17-.alpha.-éthinylestradiol, estriol, estrone, sulfate d'estrone, sulfamate d'estrogène, 17-.alpha.-estradiol, mestranol, stilbestrol et des oestrogènes conjugués naturels, et en ce que l'anti-oestrogène est un 7.alpha.-(?-aminoalkyl)-estratriène de la formule générale (I). Cette préparation combinée peut s'utiliser pour l'hormonothérapie substitutive.

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