Combination therapies employing platelet aggregation drugs

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/08 (2006.01) A61K 31/4365 (2006.01) A61K 31/616 (2006.01) A61K 31/675 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2570048

The present invention provides pharmaceutical compositions comprising a platelet aggregation inhibitor and a compound selected from pyridoxal-5'- phosphate, a pyridoxal-5'-phosphate related compound or a pharmaceutically acceptable salt thereof and methods for using a platelet aggregation inhibitor and a compound selected from pyridoxal-5'-phosphate, a pyridoxal-5'-phosphate related compound or a pharmaceutically acceptable salt thereof, for inhibiting platelet aggregation, for treating diseases that arise from prothrombotic and thrombotic states in which the coagulation cascade is activated and for reducing the risk of cardiovascular disease or cerebrovascular disease.

L'invention concerne des compositions pharmaceutiques comprenant : un inhibiteur d'agrégation plaquettaire ; et un composé sélectionné parmi pyridoxal-5'-phosphate, un composé associé à un pyridoxal-5'-phosphate ou un sel acceptable sur le plan pharmaceutique associé. L'invention concerne également des méthodes d'utilisation d'un inhibiteur d'agrégation plaquettaire et d'un composé sélectionné parmi pyridoxal-5'-phosphate, un composé associé à un pyridoxal-5'-phosphate ou un sel acceptable sur le plan pharmaceutique associé, pour inhiber l'agrégation plaquettaire, traiter des maladies provoquées par des états prothrombotiques et thrombotiques dans lesquels la cascade de coagulation est activée et pour réduire le risque de maladies cardiovasculaires ou cérébrovasculaires.

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