Combination therapies employing vitamin b6 related compounds...

A - Human Necessities – 61 – K

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Details

A61K 31/675 (2006.01) A61K 31/401 (2006.01) A61K 31/403 (2006.01) A61K 31/4355 (2006.01) A61K 31/4415 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2575849

The present invention provides the use of an angiotensin-converting enzyme (ACE) inhibitor (e.g. benazepril, captopril, enalapril, enalaprilat, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, and/or trandolapril) in combination with a vitamin B6 related compound (e.g.pyridoxal, pyridoxal-5~phosphate, pyridoxamine, a 3-acylated analogue of pyridoxal, a 3-acylated analogue of pyridoxal-4,5-aminal, and/or a pyridoxine phosphate analogue) for the treatment of diabetes and diabetic related disorders including hypertension, nephropathy, insulin sensitivity, insulinemia, hyperglycemia, hyperlipidemia, LDL and HDL levels, HbA1c levels, endothelial function, vascular function, peripheral vascular disease, atherothrombosis, atherosclerosis, nephropathy, and retinopathy

La présente invention concerne l'utilisation d'un inhibiteur d'une enzyme de conversion de l'angiotensine (ACE) (par exemple le benazépril, le captopril, l'énalapril, l'énalaprilat, le fosinopril, le lisinopril, le moexipril, le perindopril, le quinapril, le ramipril et/ou le trandolapril) en association avec un composé apparenté à la vitamine B6 (par exemple le pyridoxal, le pyridoxal-5'-phosphate, la pyridoxamine, un analogue du pyridoxal acétylé en position 3, un analogue du pyridoxal-4,5-aminal acétylé en position 3 et/ou un analogue du phosphate de pyridoxine) pour le traitement du diabète et de troubles liés au diabète dont l'hypertension, la néphropathie, la sensibilité à l'insuline, l'insulinémie, l'hyperglycémie, l'hyperlipidémie, des niveaux élevés de LDL et HDL, des niveaux élevés de HbA1c, des troubles de la fonction endothéliale, des troubles de la fonction vasculaire, une maladie vasculaire périphérique, l'athérothrombose, l'athérosclérose, la néphropathie et la rétinopathie.

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