Combination therapies for inhibiting integrin-extracellular...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2619654

The present application relates to compositions of extracellular matrix (ECM) antagonists and their use in methods for treating angiogenic-dependent conditions. The ECM antagonists can bind the same or different ECM component. The present application also relates to compositions of ECM antagonists and cancer therapies and their use in methods for preventing, treating or managing angiogenic- dependent conditions such as cancer.

L'invention concerne des compositions d'antagonistes de la matrice extracellulaire (ECM) et l'utilisation de celles-ci pour traiter des états pathologiques dépendant de l'angiogenèse. Les antagonistes de l'ECM peuvent se lier à un seul et même composant de l'ECM ou à des composants différents. L'invention concerne aussi des compositions d'antagonistes de l'ECM et des traitements anticancéreux, et leur utilisation pour prévenir, traiter ou régulariser des états pathologiques dépendant de l'angiogenèse tels que le cancer.

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