A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/52 (2006.01) A61K 31/7052 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2477422
The present invention is directed to combination therapies fro treating cell proliferative disorders associated with methylthioadenosine phosphorylase (MTAP) deficient cells in a mammal. The combination therapies selectively kill MTAP-deficient cells by administering an ihibitor of de novo inosinate synthesis and administering an anti-toxicity agent, wherein the inhibitors of de novo inosinate synthesis are inhibitors of glycinamide ribonucleotide formyltransferase ("GARFT") and/or aminoinidazolecarboximide ribonucleotide formyltransferase ("AICARFT"), and the anti-toxicity agent is an MTAP substrate (e.g. methylthioadenosine or "MTA"), a precursor of MTA, an analog of an MTA precursor or a prodrug of an MTAP substrate.
La présente invention concerne des polythérapies destinées au traitement de troubles à prolifération cellulaire liés à une déficience cellulaire en méthylthioadénosine phosphorylase (MTAP) chez un mammifère. Ces polythérapies tuent sélectivement les cellules déficientes en MTAP, par administration d'un inhibiteur de synthèse de novo et administration d'un anti-toxique. En l'occurrence, les inhibiteurs de synthèse de novo sont des inhibiteurs de glycinamide ribonucléotide formyltransférase ("GARFT") et/ou d'aminoinidazolecarboximide ribonucléotide formyltransférase ("AICARFT"), l'antitoxique étant un substrat MTAP (par exemple, méthylthioadénosine ou "MTA"), un précurseur de MTA, un analogue d'un précurseur de MTA, ou un promédicament d'un substrat MTAP.
Bloom Laura Anne
Boritzki Theordore James
Kuhn Leslie Ann
Kung Pei-Pei
Meng Jerry Jialun
Limited Pfizer
Sim & Mcburney
LandOfFree
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