Combination therapies using hdac inhibitors

Details Combination therapies using hdac inhibitors Combination therapies using hdac inhibitors

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 31/337 (2006.01) A61K 31/513 (2006.01) A61K 31/517 (2006.01) A61K 31/555 (2006.01) A61K 31/573 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2596210

The present invention pertains to a method for treating cancer, such as lung cancer, multiple myeloma, lymphoma, and epithelial ovarian cancer, comprising the administration to a patient in need thereof a first amount or dose of a histone deacetylase (HDAC) inhibitor, such as PXD-101, and a second amount or dose of another chemotherapeutic agent, such as dexamethasone or 5- fluorouracil, or an epidermal growth factor receptor (EGFR) inhibitor, such as TarcevaÚ, wherein the first and second amounts or doses together comprise a therapeutically effective amount.

La présente invention se rapporte à une méthode destinée à traiter un cancer, tel qu'un cancer du poumon, un myélome multiple, un lymphome ou un cancer de l'ovaire épithélial. La méthode selon l'invention consiste à administrer à un patient concerné une première quantité ou dose d'un inhibiteur de l'histone désacétylase (HDAC), tel que PXD-101, et une seconde quantité ou dose d'un autre agent chimiothérapeutique, tel que la dexaméthasone ou le 5-fluorouracil, ou d'un inhibiteur du récepteur du facteur de croissance épidermique (EGFR), tel que Tarceva®, les première et seconde quantités ou doses formant conjointement une dose thérapeutiquement efficace.

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