Combination therapies with vascular damaging activity

Details Combination therapies with vascular damaging activity Combination therapies with vascular damaging activity

A - Human Necessities

61

K

A61K 31/661 (2006.01) A61K 31/282 (2006.01) A61K 31/337 (2006.01) A61K 31/66 (2006.01) A61K 33/24 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2402539

The invention relates to a method for the production of a vascular damaging effect in a warm-blooded animal such as a human, which comprises administering to said animal an effective amount of ZD6126 or a pharmaceutically acceptable salt thereof, before, after or simultaneously with an effective amount of one of the following therapies: i) ionising radiation; ii) a platinum anti-tumour agent; and iii) a taxane. The invention also relates to the use of ZD6126 and one of the above therapies in the manufacture of a medicament for use in the production of a vascular damaging effect in a warm-blooded animal such as a human and to pharmaceutical compositions and kits each comprising ZD6126 and one of a platinum anti-tumour agent and a taxane.

L'invention concerne une méthode induisant un effet de détérioration vasculaire chez un animal à sang chaud, tel que l'homme. La méthode consiste à administrer à l'animal une quantité effective de ZD6126 ou d'un sel pharmaceutiquement acceptable de ladite substance avant, après ou simultanément avec une quantité effective d'un des éléments thérapeutiques suivants: i) un rayonnement d'ionisation; ii) un agent anticancéreux au platine; et iii) un taxane. L'invention concerne également l'utilisation de ZD6126 et d'un desdits éléments thérapeutiques dans la fabrication d'un médicament destiné à induire un effet de détérioration vasculaire chez un animal à sang chaud, tel que l'homme. Elle concerne en outre des compositions pharmaceutiques et des trousses comprenant chacune ZD6126 et un agent anticancéreux au platine ou un taxane.

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